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Drug Information Fulltext is produced by the American Society of Health-System Pharmacists. Questions concerning file content should be directed to: American Society of Health-System Pharmacists Emily Morris 7272 Wisconsin Avenue Bethesda, MD 20814 Phone: 1-301-664-8647 Fax: 1-301-664-8857 E-Mail: pdiso ashp. Suzanne F. Bradley, MD Geriatric Medicine and Infectious Diseases University of Michigan Medical School, for instance, how fast does diflucan work. 1 Master Student of Forensic Sciences, University of Porto, Portugal; 2 Laboratory of Forensic Toxicology, National Institute of Legal Medicine, Porto, Portugal; 3 REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto R. Anbal Cunha, 164, i 4099 Porto, Portugal.

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Objectives: Los Angeles County LAC ; experienced a resurgence of syphilis among men who have sex with men MSM ; in 2001, after initial control efforts, including a two-month media campaign, seemed to have controlled a 2000 outbreak. LAC DHS consequently funded a $396, 000 social marketing campaign for 2002-03, to increase awareness among MSM regarding syphilis and motivate testing. To maximize effectiveness and buyin of the affected population, the campaign was developed and managed by a coalition of six ethnically diverse community organizations serving MSM and funded for an entire year. Collaboration with the San Francisco Department of Public Health was also undertaken, to address possible transmission between localities. Methods: The community coalition reviewed concepts, prototype materials, and focus group responses. The selected concept, Stop the Sores, featured a cartoon format and a recurrent character, "Phil, " the syphilis sore. A perceived concept advantage was the use of humor to counteract feelings among MSM of being overwhelmed with negative sexual health messages; attention to this issue was greatly enhanced through community involvement in the campaign. Use of a recurrent character enabled use of serial narratives involving Phil, to sustain interest in the campaign over a long period. A website created for the campaign stopthesores ; , together with the STD Program hotline, provided testing linkages and flomax.
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Rita DeBate, Ph.D., M.P.H., CHES, Marcus Plescia, M.D., M.P.H., Denis Joyner, M.P.H., LaPronda Spann, BS Presented by: Rita DeBate, Ph.D., M.P.H., CHES, Assistant Professor, Health Behavior and Administration, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 29201; Tel: 704.687.2866; Fax: 704.687.6122; E-mail: rdigioac email.uncc Research Objective: The Charlotte REACH 2010 project is part of a national collaborative effort of the Centers for Disease Control and Prevention to eliminate health disparities among identified population groups through community driven interventions. The Charlotte initiative focuses on the reduction and control of cardiovascular disease and diabetes in the Northwest Corridor of Charlotte. An ecological perspective of health promotion was utilized as the framework for a Charlotte community-based intervention to eliminate health disparities in cardiovascular disease and diabetes. This ecological approach involves interventions targeted on five levels of influence with interaction between levels creating a supportive system for sustained change. In order to create sustained change, all levels of influence must be addressed and designed to work together to create a strong, supportive environment for change. Due to the complexity of multileveled ecological interventions, feedback on the process and impacts of the activities is crucial for ensuring success.The purpose of this qualitative assessment was to explore changes that have occurred among and between the following levels of influence: intrapersonal, interpersonal, organizational, community, and policy. Study Design: An exploratory assessment of the Charlotte REACH initiative was conducted using focus group methodology. A qualitative approach was chosen for this assessment as it enabled the researchers to facilitate an exploration of the process and initial impacts of the ecologically framed health promotion program. Qualitative methodology included 10 focus groups. Three independent coders hand-coded all focus groups utilizing modified coding methods developed by Spradley. Coding was then compared and an agreement of final codes was reached. Final codes were entered into NVivo qualitative analysis software. Once entered, codes were compared and contrasted into overarching themes and sub-themes. Population Studied: The geographic area of this initiative is bordered by three connected thoroughfares and contains a population of 19, 670 of which approximately 95% are African American. Local health disparities in cardiovascular disease and diabetes have been documented in community health surveys and assessments. This qualitative assessment consisted of 10 focus groups. The focus groups were conducted with the Charlotte REACH Lay Health Advisors 1 ; Charlotte REACH program staff 1 ; , residents of the target population who have participated in Charlotte REACH program activities 4 ; , and residents of the target area who had not participated in Charlotte REACH activities 4 ; . Principal Findings: A total of 84 participants were involved in the focus groups; 12 Lay Health Advisors, 6 program staff, and 66 community residents 29 who participated in REACH activities and 37 who have not participated in REACH activities ; . The focus group methodology implemented in this exploratory assessment yielded rich descriptive data regarding the status. This disease is caused by Vibrio cholerae bacteria, which are commonly transmitted by contaminated food and water. Cholera sometimes causes life-threatening diarrhea, but large numbers of bacteria must be consumed and the severe form of the disease is rarely seen in healthy tourists who follow prudent dietary habits. Cholera occurs both sporadically and in worldwide epidemics. Sub-Saharan Africa has the highest reported cholera incidence and mortality rates in the world. By the end of 1999 61 countries reported cases, but the disease is much more widespread than officially recognized. Cholera is basically a disease of poverty, and most illness occurs among people in lesser-developed countries who are exposed to heavily contaminated water or food. Most travelers on a tourist itinerary don't need to worry about this disease. In fact, cholera is officially reported in only 1 in 500, 000 returning travelers. The healthy people who do get the disease often work in high-risk environments, such as refugee camps. Unlike some microbes, cholera bacteria are readily killed by stomach acid. However, if you do ingest a large dose of bacteria from heavily contaminated water--or if you are taking antacids or antiulcer drugs--bacteria can get past the stomach and enter your small intestine. Cholera enterotoxin then acts on the intestinal wall to cause an outpouring of water and salt into the gut. The clinical picture of cholera varies widely. Seventy-five percent of infections are mild or without any symptoms. Only 2%5% of infections cause severe symptoms. Cholera in its most severe form is characterized by massive watery diarrhea, vomiting, and muscle cramps. Vomiting is common and may be severe. The frequent, watery stools soon lose all fecal appearance "rice water stools" ; and practically all odor. Loss of fluids and electrolytes can cause shock and death in hours if fluids are not replaced. Milder cases of cholera can mimic travelers' diarrhea caused by toxigenic E. coli, salmonella, intestinal viruses, and parasites. 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